SBR00088

Rilpivirine

≥95% (HPLC), powder

• Synonym(s): 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, R 278474, TMC 278
• Empirical Formula (Hill Notation): C₂₂H₁₈N₆
• CAS Number: 500287-72-9
• Molecular Weight: 366.42
• MDL number: MFCD11046372
• UNSPSC Code: 51101500

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to yellow, or beige
• antibiotic activity spectrum: viruses
• mode of action: enzyme | inhibits
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N
• InChI: 1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+

Description

General description

Rilpivirine is an antibiotic which belongs to the class of compounds known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Biochem/physiol Actions

Nonnucleoside reverse transcriptase inhibitor (NNRTI); anti-retroviral

Rilpivirine inhibits the activity of the reverse transcriptase enzyme, which is essential for the replication of HIV-1. Specifically, it binds to a specific site on the enzyme and blocks its activity, thereby preventing the conversion of viral RNA into DNA, which is an essential step for the integration of viral DNA into host cells.

Rilpivirine is a next generation nonnucleoside reverse transcriptase inhibitor (NNRTI), It has been shown to be active against many HIV strains with mutations that confer resistance to the first-generation NNRTIs.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable