SCP0224

Prostate Specific Antigen Substrate

≥95% (HPLC), lyophilized

• Synonym(s): KLK3, Kallikrein-related peptidase-3, PSA
• Empirical Formula (Hill Notation): C₄₄H₆₄N₁₂O₁₃
• Molecular Weight: 969.05
• UNSPSC Code: 12352204
• NACRES: NA.32

Properties

• Product Name: Prostate Specific Antigen Substrate,
• assay: ≥95% (HPLC)
• form: lyophilized
• composition: Peptide Content, ≥75%
• storage condition: protect from light
• storage temp.: −20°C

Description

Amino Acid Sequence

Mu-His-Ser-Ser-Lys-Leu-Gln-AMC

General description

Prostate specific antigen (PSA) is a kallikrein-related serine peptidase that belongs to the chymotrypsin subfamily serine protease. It was originally found in human semen. PSA is also detected in serum correlated to benign and metastatic disease.

Application

Prostate Specific Antigen Substrate has been used to assay recombinant severe acute respiratory syndrome coronavirus-2 viral 3-chymotrypsin-like cysteine protease (SARS-CoV-2 3CLpro).

Biochem/physiol Actions

Prostate specific antigen (PSA). It exhibits chymotrypsin-like activity. PSA is the most abundant protease found in the prostate and secreted into the seminal fluid. It is a useful biomarker for prostate cancer. PSA digests the gel-forming proteins semenogelins I and II in semen. It shows antiangiogenic activity in vitro and in vivo.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable