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SMB00209

Sigma-Aldrich

Nimbidiol

≥95% (LC/MS-ELSD)

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About This Item

Empirical Formula (Hill Notation):
C17H22O3
CAS Number:
113332-25-5
Molecular Weight:
274.35
UNSPSC Code:
12352205
PubChem Substance ID:
329824870
NACRES:
NA.25
Pricing and availability is not currently available.

assay

≥95% (LC/MS-ELSD)

form

solid

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

CC1(C)CCC[C@@]2(C)C1CC(=O)c3cc(O)c(O)cc23

InChI

1S/C17H22O3/c1-16(2)5-4-6-17(3)11-8-14(20)13(19)7-10(11)12(18)9-15(16)17/h7-8,15,19-20H,4-6,9H2,1-3H3/t15?,17-/m1/s1

InChI key

JMBKXUYCBVKSSY-OMOCHNIRSA-N

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conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

General description

Natural product derived from plant source.
Nimbidiol is a modified diterpenoid. It is isolated from the root-bark of Azadirachta indica (Indian ‘neem′).[1]

Biochem/physiol Actions

Nimbidiol has an ability to inhibit intestinal glucosidases, including maltase-glucoamylase, sucrase-isomaltase, lactase, trehalase and fungal α-glucosidases. Thus, this bioactive molecule has all the potential to be used as an anti-diabetic drug [2]

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    12222840V
    122228-40V

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    Nimbidiol, a modified diterpenoid of the root-bark of Azadirachta indica
    Majumder P L, et al.
    Phytochemistry, 26(11), 3021-3023 (1987)
    Abhishek Mukherjee et al.
    Journal of enzyme inhibition and medicinal chemistry, 28(5), 900-910 (2012-07-19)
    Azadirachta indica, used in antidiabetic herbal drugs, was reported to contain α-glucosidase inhibitor. Bioassay guided purification characterized the inhibitor as nimbidiol (a diterpenoid), present in root and stem-bark of the tree. Nimbidiol inhibited intestinal (mammalian) maltase-glucoamylase, sucrase-isomaltase, lactase, trehalase and

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