SML0374

U-104

≥98% (HPLC)

• Synonym(s): 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide, NSC 213841
• Empirical Formula (Hill Notation): C₁₃H₁₂FN₃O₃S
• CAS Number: 178606-66-1
• Molecular Weight: 309.32
• MDL number: MFCD00159265
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825375
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >15 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2
• InChI: 1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
• InChI key: YJQZNWPYLCNRLP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

U-104 is a carbonic anhydrase IX (CAIX) inhibitor and a CAXII inhibitor.

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable