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SML0572

Sigma-Aldrich

Valspodar

≥98% (HPLC)

Synonym(s):

6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D, Amdray, PSC833, [3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin

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About This Item

Empirical Formula (Hill Notation):
C63H111N11O12
CAS Number:
121584-18-7
Molecular Weight:
1214.62
MDL number:
MFCD00907207
UNSPSC Code:
12161501
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

shipped in

wet ice

storage temp.

−20°C

SMILES string

N1([C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C1=O)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)C(=O)[C@@H](C\C=C\C)C)C)C(C)C)C

InChI

1S/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-52H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46+,47+,49+,50+,51+,52+/m1/s1

InChI key

YJDYDFNKCBANTM-QCWCSKBGSA-N

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Show Differences

1 of 4

This Item
MABN540SAB4501323SAB5200718
Anti-mGluR5 Antibody, clone 11D9.1 clone 11D9.1, from mouse

MABN139

Anti-mGluR5 Antibody, clone 11D9.1

Anti-mGluR5 Antibody, clone N75/33 clone N75/33, from mouse

MABN540

Anti-mGluR5 Antibody, clone N75/33

Anti-GRM5 antibody produced in rabbit affinity isolated antibody

SAB4501323

Anti-GRM5 antibody produced in rabbit

Monoclonal Anti-Mglur1/5 - Apc antibody produced in mouse clone S75-33, purified immunoglobulin

SAB5200718

Monoclonal Anti-Mglur1/5 - Apc antibody produced in mouse

Gene Information

human ... GRM5(2915)

Gene Information

human ... GRM5(2915)

Gene Information

human ... GRM5(2915)

Gene Information

rat ... Grm5(24418)

species reactivity

human, rat

species reactivity

human, mouse, rat

species reactivity

mouse, rat, human

species reactivity

mouse, human, rat

clone

11D9.1, monoclonal

clone

N75/33, monoclonal

clone

polyclonal

clone

S75-33, monoclonal

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

mouse

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Application

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.[1]

Biochem/physiol Actions

Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor.
Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
106M4727V
026M4775V
125M4727V
025M4708V
123M4733V

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P Kielczynski et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 46(1), 233-238 (2008-02-02)
In this paper the theoretical analysis and the results of testing of a piezoelectric cantilever for the investigation of material surfaces are presented. The cantilever consists of a thin piezoelectric plate bonded with a thin metal (e.g., molybdenum) foil. The
Charles F Baker et al.
Dalton transactions (Cambridge, England : 2003), (9)(9), 1298-1303 (2004-07-15)
New molybdenum(VI) nitride oxides were synthesised by the reaction of strontium nitride and calcium nitride with molybdenum foil at high temperature in sealed stainless steel crucibles. The reactions yielded single crystalline products determined by X-ray diffraction to form complex structures
J G Watkins et al.
The Review of scientific instruments, 79(10), 10F125-10F125 (2008-12-03)
Two modular arrays of Langmuir probes designed to handle a heat flux of up to 25 MW/m(2) for 10 s exposures have been installed in the lower divertor target plates of the DIII-D tokamak. The 20 pyrolytic graphite probe tips
Michael N Evans
Rapid communications in mass spectrometry : RCM, 22(14), 2211-2219 (2008-06-11)
A reactor for converting cellulose into carbon monoxide for subsequent oxygen isotopic analysis via continuous flow isotope ratio mass spectrometry is described. The system employs an induction heater to produce temperatures >or=1500 degrees C within a molybdenum foil crucible positioned
Dattatray J Late et al.
Nanotechnology, 19(26), 265605-265605 (2008-07-02)
Nanocrystalline lanthanum hexaboride (LaB(6)) films have been deposited on molybdenum foil by the pulsed laser deposition (PLD) technique. The as-deposited films were characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The XRD pattern shows
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