SML1110

Adaphostin

≥98% (HPLC)

• Synonym(s): 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoic acid tricyclo[3.3.1.13,7]dec-1-yl ester, AG 957 Adamantyl Ester, NSC 680410
• Empirical Formula (Hill Notation): C₂₄H₂₇NO₄
• CAS Number: 241127-58-2
• Molecular Weight: 393.48
• MDL number: MFCD06411386
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825651
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC=C(NCC2=CC(O)=CC=C2O)C=C1)OC34C[C@@]5([H])C[C@@](C[C@@](C5)([H])C4)([H])C3
• InChI: 1S/C24H27NO4/c26-21-5-6-22(27)19(10-21)14-25-20-3-1-18(2-4-20)23(28)29-24-11-15-7-16(12-24)9-17(8-15)13-24/h1-6,10,15-17,25-27H,7-9,11-14H2/t15-,16+,17-,24-
• InChI key: YJZSUCFGHXQWDM-ONHXBKDTSA-N

Description

Biochem/physiol Actions

Adaphostin is a p210bcr/abl tyrosine kinase inhibitor and a potent inducer of myeloid cell death.

Adaphostin is a p210bcr/abl tyrosine kinase inhibitor displaying anti-proliferative activity in leukemia models, human prostate cancer cell line PC-3 and other cancer cell lines. Adaphostin is a potent inducer of myeloid cell death. Similarly to AG957, adaphostin appears to induce a degradation of WT and mutated Bcr/Abl.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable