SML1278
Geldanamycin Ready Made Solution
1 mg/mL, from Streptomyces hygroscopicus
Synonym(s):
2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
Sign Into View Organizational & Contract Pricing
Select a Size
All Photos(1)
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C29H40N2O9
CAS Number:
Molecular Weight:
560.64
UNSPSC Code:
12352200
NACRES:
NA.77
biological source
Streptomyces hygroscopicus
Quality Level
form
DMSO solution
storage condition
protect from light
concentration
1 mg/mL
antibiotic activity spectrum
neoplastics
mode of action
enzyme | inhibits
shipped in
dry ice
storage temp.
−20°C
SMILES string
N1C2=CC(=O)C(=C(C[C@H](C[C@@H]([C@@H]([C@H](\C=C(\[C@@H]([C@H](\C=C/C=C(/C1=O)\C)OC)OC(=O)N)/C)C)O)OC)C)C2=O)OC
Related Categories
General description
Chemical structure: benzenoid
Application
Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.
Biochem/physiol Actions
Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
188.6 °F
flash_point_c
87 °C
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service