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SML1637

Sigma-Aldrich

Hexaminolevulinate hydrochloride

≥98% (HPLC)

Synonym(s):

5-Aminolevulinic acid hexyl ester HAL hydrochloride, 5-Aminolevulinic acid hexyl ester hydrochloride, HAL, Hexvix, Hexyl 5-aminolevulinate hydrochloride, P 1206, n-Hexyl 5-aminolevulinate hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H21NO3 · HCl
CAS Number:
Molecular Weight:
251.75
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

room temp

SMILES string

CCCCCCOC(CCC(CN)=O)=O.[H]Cl

InChI

1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H

InChI key

LZYXPFZBAZTOCH-UHFFFAOYSA-N

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1 of 4

This Item
1.0967176887360481
grade

ACS reagent

grade

ACS reagent

grade

analytical standard

grade

ACS reagent

refractive index

n20/D 1.422 (lit.)

refractive index

-

refractive index

n20/D 1.422 (lit.)

refractive index

n20/D 1.422 (lit.)

density

1.034 g/mL at 25 °C (lit.)

density

1.03 g/cm3 at 20 °C

density

1.034 g/mL at 25 °C (lit.)

density

1.034 g/mL at 25 °C (lit.)

bp

100-102 °C (lit.)

bp

101.5 °C/1013 hPa

bp

100-102 °C (lit.)

bp

100-102 °C (lit.)

vapor pressure

27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

vapor pressure

41 hPa ( 20 °C)

vapor pressure

27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

vapor pressure

27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

vapor density

3 (vs air)

vapor density

-

vapor density

3 (vs air)

vapor density

3 (vs air)

Biochem/physiol Actions

Hexaminolevulinate (HAL) hydrochloride is a hexyl ester of 5-Aminolevulinic acid (ALA), a precursor to porphyrins including the photosensitizer protoporphyrin IX (PPIX). Hexaminolevulinate is more lipophilic than ALA, and is 50–100 times more efficient than ALA at inducing PpIX, which accumulates preferentially in neoplastic cells. Hexaminolevulinate administration followed by light activation has been used for fluorescence cystoscopy to enhance detection of bladder cancer, in particular carcinoma in situ (CIS). Hexaminolevulinate is also being studied for use in cancer photodynamic therapy. Hexaminolevulinate followed by irradiation produced DNA oxidative damage and apoptosis.
Hexaminolevulinate is a hexyl ester of 5-Aminolevulinic acid; imaging agen for fluorescence cyctoscopy; photosensitizer.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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