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SML2047

Sigma-Aldrich

BPAM344

≥98% (HPLC)

Synonym(s):

BPAM344, 4-Cyclopropyl-3,4-dihydro-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C10H11FN2O2S
CAS Number:
1204572-55-3
Molecular Weight:
242.27
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

storage temp.

2-8°C

SMILES string

O=S1(C2=CC(F)=CC=C2N(C3CC3)CN1)=O

InChI

1S/C10H11FN2O2S/c11-7-1-4-9-10(5-7)16(14,15)12-6-13(9)8-2-3-8/h1,4-5,8,12H,2-3,6H2

InChI key

FLTMTBPCYAZIKM-UHFFFAOYSA-N

Biochem/physiol Actions

BPAM344 is a potent positive allosteric modulator (PAM) on the three KAR subunits GluK1b, GluK2a, and GluK3a. BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold, and noticeably decreases desensitization kinetics (from 5.5 to 775 ms).
Potent positive allosteric modulator (PAM) on the three KAR subunits GluK1b, GluK2a, and GluK3a

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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