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SML2276

Sigma-Aldrich

TH-263

≥98% (HPLC)

Synonym(s):

4-[(Phenylamino)sulfonyl]-N-(phenylmethyl)benzamide, N-Benzyl-4-(benzylsulfamoyl)benzamide

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About This Item

Empirical Formula (Hill Notation):
C20H18N2O3S
CAS Number:
1004044-80-7
Molecular Weight:
366.43
UNSPSC Code:
12352200

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=C(C=C1)S(NC2=CC=CC=C2)(=O)=O)NCC3=CC=CC=C3

Biochem/physiol Actions

Inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-251, TH-255 and TH-257.
TH263 is an inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251. For characterization details of the active probe, TH-257, please visit the TH-257 probe summary on the Structural Genomics Consortium (SGC) website.

TH-257, the active probe, is available from Sigma. To learn more about and purchase TH-257, click here.

To learn about other SGC chemical probes, visit sigma.com/sgc

Features and Benefits

TH-236 is a negative control for TH-257, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Risa Kashima et al.
Science signaling, 10(477) (2017-05-04)
Fragile X syndrome (FXS) is the most common cause of heritable intellectual disability and autism and affects ~1 in 4000 males and 1 in 8000 females. The discovery of effective treatments for FXS has been hampered by the lack of
Nicole C Goodwin et al.
ACS medicinal chemistry letters, 6(1), 53-57 (2015-01-16)
The first allosteric, type III inhibitor of LIM-kinase 2 (LIMK2) is reported. A series of molecules that feature both an N-phenylsulfonamide and tertiary amide were not only very potent at LIMK2 but also were extremely selective against a panel of

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