SML2434

TP-238 Hydrochloride

≥98% (HPLC)

• Synonym(s): 1-(3-(6-(4-(3-dimethylamino-propoxy)-phenyl)-2-methylsulfonyl-pyrimidin-4-ylamino)-propyl)-1H-pyrazole Hydrochloride, N-(3-(1H-Pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine hydrochloride
• Empirical Formula (Hill Notation): C₂₂H₃₀N₆O₃S · xHCl
• Molecular Weight: 458.58 (free base basis)
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C

Description

Biochem/physiol Actions

Chemical probe for CECR2/BPTF bromodomains

TP-238 is a chemical probe for CECR2 (cat eye syndrome chromosome region, candidate 2), a gene expressed in the nervous system involved in neurulation, and for BPTF bromodomains. It has an activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 showed an IC₅₀ of 30nM against CECR2 and 350nM against BPTF in an alphascreen assay and a KD of 10nM for CECR2 and 120nM for BPTF by ITC. The structurally related negative control TP-422 is completely inactive against BPTF and CECR2.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable