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SML2450

Sigma-Aldrich

BIIE 0246 hydrochloride

≥98% (HPLC)

Synonym(s):

AR-H 053591 hydrochloride, BIIE-0246 hydrochloride, N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]cyclopentaneacetamide

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About This Item

Empirical Formula (Hill Notation):
C49H57N11O6 · xHCl
CAS Number:
246146-55-4
Molecular Weight:
896.05 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[n]2([n]([c]([n]([c]2=O)CCNC(=O)[C@@H](NC(=O)CC8(CCCC8)CC(=O)N4CCN(CC4)C5c6c(cccc6)NC(=O)c7c5cccc7)CCCNC(=N)N)=O)c3ccccc3)c1ccccc1

InChI

1S/C49H57N11O6/c50-46(51)53-25-13-22-40(45(64)52-26-27-58-47(65)59(34-14-3-1-4-15-34)60(48(58)66)35-16-5-2-6-17-35)54-41(61)32-49(23-11-12-24-49)33-42(62)56-28-30-57(31-29-56)43-36-18-7-8-19-37(36)44(63)55-39-21-10-9-20-38(39)43/h1-10,14-21,40,43H,11-13,22-33H2,(H,52,64)(H,54,61)(H,55,63)(H4,50,51,53)/t40-,43?/m0/s1

InChI key

RSJAXPUYVJKAAA-JPGJPTAESA-N

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EMU092081EMU027991EMU054601
MISSION® esiRNA targeting mouse Suv39h1

EMU052961

MISSION® esiRNA

MISSION® esiRNA targeting mouse Suclg2

EMU092081

MISSION® esiRNA

MISSION® esiRNA targeting mouse Tnfrsf1a

EMU027991

MISSION® esiRNA

MISSION® esiRNA targeting mouse Syngr2

EMU054601

MISSION® esiRNA

esiRNA cDNA target sequence

CCTGCCCTTGGTGTTTCTAAGAAGAATCTGTATGACTTTGAAGTTGAATACCTGTGTGATTATAAGAAGATCCGTGAGCAGGAGTATTACCTGGTTAAGTGGCGTGGGTATCCCGACTCAGAAAACACCTGGGAGCCACGGCAGAATCTAAAATGTATACGAGTTCTTAAGCAGTTCCACAAGGACTTAGAAAGAGAGCTTGTCCGACGACACCGCCGGTCAAAGCCACCCAGGCATCTGGACCCAAACCTAGCCAATTACCTGGTGCAGAAGGCCAAGCAGAGGCGGGCACTTCAGCGTTGGGAACAAGAGCTCAATGCCAAGCGCAGCCACCTGGGGCGGATCACCGTGGAGAATGAGGTAGACCTGGATGGCCCTCCAAGGTCCTTTGTCTATATCAATGAGTATCGAGTTGGTGAGGGCATCACCCTCAACCAGGTAGCTGTTGGCTGTGAGTGC

esiRNA cDNA target sequence

ACCAGGCTGCAGATCAGATTACAAAGCTGTACCATCTCTTCCTGAAGATTGATGCCACTCAGGTGGAAGTGAACCCCTTCGGTGAAACTCCAGAAGGACAAGTTGTCTGTTTTGATGCCAAGATAAACTTTGATGACAATGCTGAGTTCCGACAAAAGGACATATTTGCTATGGACGACAAATCCGAGAATGAGCCCATTGAAAATGAAGCTGCCAGATACGATCTCAAGTATATAGGACTGGACGGGAACATTGCCTGCTTCGTGAATGGTGCTGGGCTGGCCATGGCTACCTGCGACATCATCTTCCTGAACGGAGGGAAGCCAGCGAACTTCTTGGACCTTGGAGGTGGTGTAAAGGAAGCCCAAGTCTATGAAGCATTCAAACTGCTCACGTCTGACCCCAAGGTGGAAGCCATTCTCGTCAATATCTTTGGTGGGATCGTCAACT

esiRNA cDNA target sequence

ACCAAGTGCCACAAAGGAACCTACTTGGTGAGTGACTGTCCGAGCCCAGGGCGGGATACAGTCTGCAGGGAGTGTGAAAAGGGCACCTTTACGGCTTCCCAGAATTACCTCAGGCAGTGTCTCAGTTGCAAGACATGTCGGAAAGAAATGTCCCAGGTGGAGATCTCTCCTTGCCAAGCTGACAAGGACACGGTGTGTGGCTGTAAGGAGAACCAGTTCCAACGCTACCTGAGTGAGACACACTTCCAGTGCGTGGACTGCAGCCCCTGCTTCAACGGCACCGTGACAATCCCCTGTAAGGAGACTCAGAACACCGTGTGTAACTGCCATGCAGGGTTCTTTCTGAGAGAAAGTGAGTGCGTCCCTTGCAGCCACTGCAAGAAAAATGAGGAGTGTATGAAGTTGTGCCTACCTCCTCCGCTTGCAAATGTCACAAACCCCCAGGACTCAGGTACTGCGGTG

esiRNA cDNA target sequence

TTCCTGTCTCAGCCTCAGGTGGTGACGCGCCTCGTGAGCATGGTCTTGGCCTTGATCGTGTTCTCCTGCATCTTCGGCGAGGGCTACACCAACATTCACACATCTGATCAACTATACTGTGTGTTCAACCAGAATGAGGATGCCTGCCGCTACGGCAGCGCCATCGGGGTGCTGGCCTTCCTGGCCTCAGCCTTCTTCCTTGTGGTCGATGCCTTCTTCTCCCAGATAAGCAATGCCACTGACCGAAAGTACCTGGTCATTGGCGACCTGCTCTTCTCAGCTCTCTGGACCTTCCTGTGGTTTGTTGGTTTCTGCTTCCTGACCAACCAGTGGGCAGCCACCAAACCTCAAGATGTCCGGGTGGGTGCGGACTCAGCTCGGGCAGCCATCACCTTCAGCTTCTTCTCCATCTTTTCCTGGGGTGTGCTGGCTTCCCTGGCCTACCAGCGCTACAAGGCTGGAGTGGATGCCTTCATT

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

Ensembl | mouse accession no.

ENSMUSG00000039231

Ensembl | mouse accession no.

ENSMUSG00000061838

Ensembl | mouse accession no.

ENSMUSG00000030341

Ensembl | mouse accession no.

ENSMUSG00000048277

Gene Information

mouse ... SUV39H1(20937), Suv39h1(20937)

Gene Information

mouse ... SUCLG2(20917), Suclg2(20917)

Gene Information

mouse ... TNFRSF1A(21937), Tnfrsf1a(21937)

Gene Information

mouse ... SYNGR2(20973), Syngr2(20973)

NCBI accession no.

NM_011514

NCBI accession no.

NM_011507

NCBI accession no.

NM_011609

NCBI accession no.

NM_009304

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Biochem/physiol Actions

BIIE0246 is a high-affinity, competitive non-peptide antagonist for the neuropeptide Y (NPY) Y2 receptor (Ki = 8-15 nM). BIIE0246 potently blocks NPY effects in rat hippocampus.
First selective non-peptide neuropeptide Y Y2 receptor antagonist

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    C Lu et al.
    Oncogene, 29(41), 5630-5642 (2010-08-03)
    Neuroblastomas are pediatric tumors that develop from sympathetic precursors and express neuronal proteins, such as neuropeptide Y (NPY). NPY is a sympathetic neurotransmitter acting via multiple receptors (Y1-Y5R). Both NPY and Y2Rs are commonly expressed in neuroblastoma cell lines and
    Y Dumont et al.
    British journal of pharmacology, 129(6), 1075-1088 (2000-03-22)
    1. BIIE0246, a newly synthesized non-peptide neuropeptide Y (NPY) Y(2) receptor antagonist, was able to compete with high affinity (8 to 15 nM) for specific [(125)I]PYY(3 - 36) binding sites in HEK293 cells transfected with the rat Y(2) receptor cDNA
    Bouchaïb El Bahh et al.
    British journal of pharmacology, 136(4), 502-509 (2002-06-11)
    Neuropeptide Y (NPY) has been shown to suppress synaptic excitation in rat hippocampus by a presynaptic action. The Y(2) (Y(2)R) and the Y(5) (Y(5)R) receptors have both been implicated in this action. We used the non-peptide, Y(2)R-selective antagonist, BIIE0246, to

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