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SML2639

Sigma-Aldrich

BDT001

≥98% (HPLC)

Synonym(s):

N-(5-Chloro-2-hydroxyphenyl)-3-(piperidin-1-ylsulfonyl) benzamide

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About This Item

Empirical Formula (Hill Notation):
C18H19ClN2O4S
CAS Number:
823837-22-5
Molecular Weight:
394.87
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC=C(C=C1NC(C2=CC=CC(S(N3CCCCC3)(=O)=O)=C2)=O)Cl

InChI key

GRZNJWNQXQKQQL-UHFFFAOYSA-N

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This Item
CLS357551CLS356521CLS357521
Corning® Falcon® Serological Pipettes capacity 10 mL, individually wrapped, clear-plastic, sterile

CLS356551

Corning® Falcon® Serological Pipettes

Corning® Falcon® Serological Pipettes capacity 10 mL, individually wrapped, paper-plastic, sterile

CLS357551

Corning® Falcon® Serological Pipettes

Corning® Falcon® Serological Pipettes capacity 1 mL, individually wrapped, clear-plastic, sterile

CLS356521

Corning® Falcon® Serological Pipettes

Corning® Falcon® Serological Pipettes capacity 1 mL, individually wrapped, clear-plastic, sterile

CLS357521

Corning® Falcon® Serological Pipettes

feature

individually wrapped clear-plastic, subdivision

feature

individually wrapped paper-plastic, subdivision

feature

individually wrapped clear-plastic, subdivision

feature

individually wrapped clear-plastic, subdivision

material

polystyrene

material

polystyrene

material

polystyrene

material

polystyrene

sterility

sterile

sterility

sterile

sterility

sterile

sterility

sterile

capacity

10 mL

capacity

10 mL

capacity

1 mL

capacity

1 mL

manufacturer/tradename

Corning 356551

manufacturer/tradename

Corning 357551

manufacturer/tradename

Corning 356521

manufacturer/tradename

Corning 357521

Biochem/physiol Actions

BDT001 is a selective negative allosteric modulator of Flt-3 receptor tyrosine kinase. It showed minimal binding to 25 diverse RTKs and 49 intracellular kinases. In primary cultures of adult DRG neurons, BDT001 reversed the potentiation of capsaicin-induced TRPV1 activation by FL, with a maximal effect at 1 μM. In a mouse study BDT001 alleviated nerve injury-induced peripheral neuropathic pain but had no effect on nociception in non-injured animals.
Negative allosteric modulator of Flt-3 receptor tyrosine kinase

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Cyril Rivat et al.
Nature communications, 9(1), 1042-1042 (2018-03-14)
Peripheral neuropathic pain (PNP) is a debilitating and intractable chronic disease, for which sensitization of somatosensory neurons present in dorsal root ganglia that project to the dorsal spinal cord is a key physiopathological process. Here, we show that hematopoietic cells

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