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SML2639

Sigma-Aldrich

BDT001

≥98% (HPLC)

Synonym(s):

N-(5-Chloro-2-hydroxyphenyl)-3-(piperidin-1-ylsulfonyl) benzamide

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About This Item

Empirical Formula (Hill Notation):
C18H19ClN2O4S
CAS Number:
823837-22-5
Molecular Weight:
394.87
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC=C(C=C1NC(C2=CC=CC(S(N3CCCCC3)(=O)=O)=C2)=O)Cl

InChI key

GRZNJWNQXQKQQL-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
MABF3175MABF3179MABF2299
Anti-IL-4 Antibody, clone 2D7.14.8

MABF3181

Anti-IL-4 Antibody, clone 2D7.14.8

Anti-IL-5 Antibody, clone 4A1.6.15

MABF3175

Anti-IL-5 Antibody, clone 4A1.6.15

Anti-IL-6 Antibody, clone 3A7.10

MABF3179

Anti-IL-6 Antibody, clone 3A7.10

Anti-IL-1α Antibody, clone 7E5.14.5

MABF2299

Anti-IL-1α Antibody, clone 7E5.14.5

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

Gene Information

mouse ... IL4(3565)

Gene Information

mouse ... IL5(3567)

Gene Information

mouse ... IL6(3569)

Gene Information

-

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

clone

2D7.14.8, monoclonal

clone

4A1.6.15, monoclonal

clone

3A7.10, monoclonal

clone

7E5.14.5, monoclonal

Biochem/physiol Actions

BDT001 is a selective negative allosteric modulator of Flt-3 receptor tyrosine kinase. It showed minimal binding to 25 diverse RTKs and 49 intracellular kinases. In primary cultures of adult DRG neurons, BDT001 reversed the potentiation of capsaicin-induced TRPV1 activation by FL, with a maximal effect at 1 μM. In a mouse study BDT001 alleviated nerve injury-induced peripheral neuropathic pain but had no effect on nociception in non-injured animals.
Negative allosteric modulator of Flt-3 receptor tyrosine kinase

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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