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SML2667

Sigma-Aldrich

AC261066

≥98% (HPLC)

Synonym(s):

4-[4-(2-Butoxyethoxy)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid, AC 261066, AC-261066

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About This Item

Empirical Formula (Hill Notation):
C17H20FNO4S
CAS Number:
870773-76-5
Molecular Weight:
353.41
MDL number:
MFCD18086924
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Fc1c(ccc(c1)c2[s]c(c(n2)OCCOCCCC)C)C(=O)O

InChI

1S/C17H20FNO4S/c1-3-4-7-22-8-9-23-15-11(2)24-16(19-15)12-5-6-13(17(20)21)14(18)10-12/h5-6,10H,3-4,7-9H2,1-2H3,(H,20,21)

InChI key

HSAOETBFVAWNRP-UHFFFAOYSA-N

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Anti-AsCas12a (Cpf1) antibody, Mouse monoclonal clone AsCpf-11, purified from hybridoma cell culture

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Anti-AsCas12a (Cpf1) antibody, Mouse monoclonal

Anti-FITC antibody, Mouse monoclonal clone FL-D6, purified from hybridoma cell culture

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Anti-FITC antibody, Mouse monoclonal

conjugate

FITC conjugate

conjugate

-

conjugate

-

conjugate

-

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

clone

7A9-3A3, monoclonal

clone

10C11-A12, monoclonal

clone

AsCpf-11, monoclonal

clone

FL-D6, monoclonal

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

UniProt accession no.

Q99ZW2

UniProt accession no.

Q99ZW2

UniProt accession no.

U2UMQ6

UniProt accession no.

-

Biochem/physiol Actions

AC261066 is an orally active, selective and potent synthetic agonist for the retinoic acid β2-receptor (RARβ2) that decreases oxidative stress in mice fed a high-fat diet. AC261066 reduce ischemia/reperfusion injury of the heart in mice models.
orally active, selective and potent synthetic agonist for the retinoic acid β2-receptor (RARβ2)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Alice Marino et al.
The Journal of pharmacology and experimental therapeutics, 366(2), 314-321 (2018-06-17)
We previously discovered that oral treatment with AC261066, a synthetic selective agonist for the retinoic acid β2-receptor, decreases oxidative stress in the liver, pancreas, and kidney of mice fed a high-fat diet (HFD). Since hyperlipidemic states are causally associated with
Birgitte W Lund et al.
Journal of medicinal chemistry, 48(24), 7517-7519 (2005-11-24)
4'-Octyl-4-biphenylcarboxylic acid (1g, AC-55649) was identified as a highly isoform-selective agonist at the human RARbeta2 receptor in a functional intact cell-based screening assay. The subsequent hit to lead optimization transformed the lipophilic, poorly soluble hit into a more potent and
Steven E Trasino et al.
Journal of molecular medicine (Berlin, Germany), 94(10), 1143-1151 (2016-06-09)
Hepatic stellate cells (HSCs) are an important cellular target for the development of novel pharmacological therapies to prevent and treat nonalcoholic fatty liver diseases (NAFLD). Using a high fat diet (HFD) model of NAFLD, we sought to determine if synthetic

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