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SML2727

Sigma-Aldrich

BAY 41-8543

≥98% (HPLC)

Synonym(s):

2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine, BAY41-8543

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About This Item

Empirical Formula (Hill Notation):
C21H21FN8O
CAS Number:
256498-66-5
Molecular Weight:
420.44
MDL number:
MFCD18382081
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to very dark brown

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Fc1c(cccc1)C[n]2nc(c5c2nccc5)c3nc(c(c(n3)N)N4CCOCC4)N

InChI

1S/C21H21FN8O/c22-15-6-2-1-4-13(15)12-30-21-14(5-3-7-25-21)16(28-30)20-26-18(23)17(19(24)27-20)29-8-10-31-11-9-29/h1-7H,8-12H2,(H4,23,24,26,27)

InChI key

AQYFUZRYBJBAGZ-UHFFFAOYSA-N

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D-Mannose 6-phosphate disodium salt hydrate ≥97.0% dry basis (enzymatic)

M6876

D-Mannose 6-phosphate disodium salt hydrate

D-Mannose 6-phosphate sodium salt ≥98% (HPLC)

M3655

D-Mannose 6-phosphate sodium salt

D-(+)-Mannose ≥99% (GC), wood

M2069

D-(+)-Mannose

α-D(+)Mannose 1-phosphate sodium salt hydrate ≥98% (TLC), Sigma Grade

M1755

α-D(+)Mannose 1-phosphate sodium salt hydrate

assay

≥97.0% dry basis (enzymatic)

assay

≥98% (HPLC)

assay

≥99% (GC)

assay

≥98% (TLC)

biological source

wood (birch wood)

biological source

synthetic (inorganic)

biological source

wood

biological source

plant (Phytolacca fructus / pokeweed)

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear to cloudy, colorless

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

−20°C

Biochem/physiol Actions

BAY 41-8543 is a stimulator of soluble Guanylyl cyclase (guanylate cyclase, sGC), the primary cellular receptor for nitric oxide (NO).
Guanylyl cyclase (sGC) stimulator

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    A Cervantes et al.
    Cancer letters, 41(2), 169-177 (1988-08-15)
    The role of oxygen-derived free radicals in the cytotoxicity of doxorubicin (Dox) was studied in a Dox sensitive human ovarian cancer cell line (A2780) and its multidrug resistant counterpart (2780AD) using reactive oxygen scavengers. In both cell lines, a significant
    Karin P Potoka et al.
    American journal of respiratory cell and molecular biology, 58(5), 636-647 (2017-12-22)
    Sickle cell disease (SCD) is associated with intravascular hemolysis and oxidative inhibition of nitric oxide (NO) signaling. BAY 54-6544 is a small-molecule activator of oxidized soluble guanylate cyclase (sGC), which, unlike endogenous NO and the sGC stimulator, BAY 41-8543, preferentially

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