SML2890

BAY-899

≥98% (HPLC)

• Synonym(s): (5S)-N-[2-(4-Fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide, (S)-N-(2-(4-Fluorophenoxy)pyrimidin-5-yl)-5-(4-fluorophenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide
• Empirical Formula (Hill Notation): C₂₅H₁₉F₂N₅O₂
• CAS Number: 2471967-92-5
• Molecular Weight: 459.45
• MDL number: MFCD32263051
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D 165 to 195°, c = 1 in chloroform-d
• color: white to beige
• solubility: DMSO: 1 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(N1[C@@H](C2=CC=C(F)C=C2)C3=C(N=CC=C3)CC1)NC4=CN=C(OC5=CC=C(F)C=C5)N=C4
• InChI: 1S/C25H19F2N5O2/c26-17-5-3-16(4-6-17)23-21-2-1-12-28-22(21)11-13-32(23)25(33)31-19-14-29-24(30-15-19)34-20-9-7-18(27)8-10-20/h1-10,12,14-15,23H,11,13H2,(H,31,33)/t23-/m0/s1
• InChI key: VKQBTIMLSDGNLG-QHCPKHFHSA-N

Description

Biochem/physiol Actions

BAY-899 is an orally available, potent and selective antagonist of the human luteinizing hormone receptor (hLH-R) that reduces sex hormone levels in several animal models. BAY-899 likely binds to a putative rhodopsin-like binding cavity located within the 7-transmembrane region of the hLH-receptor.

orally available, potent and selective antagonist of the human luteinizing hormone receptor (hLH-R)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable