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SML3010

Sigma-Aldrich

Belinostat

≥98% (HPLC)

Synonym(s):

(2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide, (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide, (E)-N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide, PX 105684, PX-105684, PX105684, PXD 101, PXD-101, PXD101

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About This Item

Empirical Formula (Hill Notation):
C15H14N2O4S
CAS Number:
866323-14-0
Molecular Weight:
318.35
MDL number:
MFCD08064035
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

[S](=O)(=O)(Nc2ccccc2)c1cc(ccc1)\C=C\C(=O)NO

InChI

1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

InChI key

NCNRHFGMJRPRSK-MDZDMXLPSA-N

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biological source

goat

biological source

goat

biological source

goat

biological source

goat

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

species reactivity

human

species reactivity

rabbit

species reactivity

rat

species reactivity

mouse

conjugate

fluorescein conjugate

conjugate

fluorescein conjugate

conjugate

fluorescein conjugate

conjugate

fluorescein conjugate

technique(s)

direct immunofluorescence: suitable, indirect immunofluorescence: suitable, indirect ELISA: suitable

technique(s)

direct immunofluorescence: suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable

technique(s)

direct immunofluorescence: suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable

technique(s)

direct immunofluorescence: suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

Biochem/physiol Actions

Belinostat (PX105684; PXD101) is a potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 41/125/30/216 nM, class IIA HDAC4/7/9 = 115/67/128 nM, class IIB HDAC6 = 82 nM) with anti-cancer efficacy in vitro and in vivo.
Potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor with anti-cancer efficacy in vitro and in vivo.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Muta. 1B - Repr. 2 - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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