SML3130

SHetA2

≥98% (HPLC)

• Synonym(s): 1-(4-Nitrophenyl)-3-(2,2,4,4-tetramethylthiochroman-6-yl)thiourea, N-(3,4-Dihydro-2,2,4,4-tetramethyl-2H-1-benzothiopyran-6-yl)-N′-(4-nitrophenyl)thiourea, NSC 726189, NSC-726189, NSC726189, Sulfur Heteroarotinoid A2
• Empirical Formula (Hill Notation): C₂₀H₂₃N₃O₂S₂
• CAS Number: 361483-66-1
• Molecular Weight: 401.55
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S=C(NC1=CC=C2SC(C)(CC(C)(C)C2=C1)C)NC(C=C3)=CC=C3[N+]([O-])=O
• InChI: 1S/C20H23N3O2S2/c1-19(2)12-20(3,4)27-17-10-7-14(11-16(17)19)22-18(26)21-13-5-8-15(9-6-13)23(24)25/h5-11H,12H2,1-4H3,(H2,21,22,26)
• InChI key: FWWKIYPMUZVMQG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Orally available chemopreventive fexible heteroarotinoid (Flex-Het) that induces cancer apoptosis in cultures and in vivo independent of retinoic acid receptor (RAR).

SHetA2 is an orally available chemopreventive fexible heteroarotinoid (Flex-Het) that inhibits cancer growth in cultures (OVCAR-3/SK-OV-3/Caov-3 GI50 = 3.9/4.1/7.0 μM) and in vivo (60-100 mg/kg SiHa xenograft mice) via apoptosis induction independent of retinoic acid receptor (RAR). SHetA2 is reported to bind heatshock proteins HSPA5 (GRP78, BiP), HSPA8 (HSC70, HSP73, HSPA10), HSPA9 (GRP75), resulting in cyclin D1 degradation.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable