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SML3405

Sigma-Aldrich

NVP-LDZ982

≥98% (HPLC)

Synonym(s):

LDZ-982, LDZ 982, LDZ982, Methyl 5-[1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl]-3-(2,6-dichlorophenyl)isoxazole-4-carboxylate, NITD 982, NITD-982, NITD982

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About This Item

Empirical Formula (Hill Notation):
C21H11Cl3F3N3O3
CAS Number:
Molecular Weight:
516.68
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

powder

color

, Light yellow to orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

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Show Differences

1 of 4

This Item
HPA035821AMAB91163HPA028911
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

Biochem/physiol Actions

Dihydroorotate dehydrogenase (DHODH) inhibitor with broad-spectrum antiviral activity against Dengue, HCV, HIV, Influenza, RSV, and Yellow fever.
NVP-LDZ982 (NITD-982) is a dihydroorotate dehydrogenase (DHODH) inhibitor (Kd = 27 nM) with broad-spectrum antiviral activity by targeting host cell de novo pyrimidine biosynthesis pathway. NITD-982 inhibits various viral replications in cultues, including Dengue (DENV EC50 = 5-2.6 nM; A549), hepatitis C virus (HCV EC50 = 7-12.6 nM; Huh-7), HIV (MDR769 EC50 = 0.97 nM; PBMC), Influenza (EC50 = 32 nM/H1N1, 117 nM/B, 217 nM/H1N3; MDCK), respiratory syncytial virus (RSV EC50 = 7-9 nM; Hep-2), and Yellow fever (strain 17D EC50 = 8.2 nM; A549).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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