SML3440

AVN-944

≥98% (HPLC)

• Synonym(s): (1R)-1-(Cyanomethyl)propyl N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]carbamate, AVN 944, VX-944, [(1S)-1-[3-[[[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]-carbamic acid (1R)-1-(cyanomethyl)propyl ester
• Empirical Formula (Hill Notation): C₂₅H₂₇N₅O₅
• CAS Number: 297730-17-7
• Molecular Weight: 477.51
• MDL number: MFCD22200574
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: N([C@@H](C)c1cc(ccc1)NC(=O)Nc2cc(c(cc2)c3[o]cnc3)OC)C(=O)O[C@H](CC)CC#N
• InChI key: GYCPCOJTCINIFZ-OXJNMPFZSA-N

Description

Biochem/physiol Actions

AVN-944 is an orally bioavailable, highly selective, nonnucleoside and uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with antitumor and antiviral activities. AVN-944 depletes intracellular GMP levels and inhibits DNA and RNA viruses replication via reduction of GTP pools in infected cells. Arrests a wide range of hematologic and epithelial tumor cell types proliferation (IC50 of 0.02 µM to 0.279 µM).

Orally bioavailable, highly selective, nonnucleoside and uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with antitumor and antiviral activities

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable