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SML3458

Sigma-Aldrich

KL-11743

≥98% (HPLC)

Synonym(s):

2-(3-(6-Ethoxy-4-((4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenyl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide, 2-[3-[6-Ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)acetamide

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About This Item

Empirical Formula (Hill Notation):
C30H30N6O3
CAS Number:
1369452-53-8
Molecular Weight:
522.60
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

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Show Differences

1 of 4

This Item
JKA13015JKA13020JKA13001
mPEG5-SH

JKA13012

mPEG5-SH

mPEG12-SH

JKA13015

mPEG12-SH

mPEG5-NH2

JKA13020

mPEG5-NH2

mPEG6-NH2

JKA13001

mPEG6-NH2

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

shape: linear
functionality: monofunctional

form

liquid

form

liquid

form

liquid

form

liquid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Biochem/physiol Actions

KL-11743 is an orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo. It induces aspartate accumulation and increases mitochondrial metabolism. KL-11743 specifically inhibits the growth of tumors containing truncated the tricarboxylic acid (TCA) cycle due to mutations inactivating succinate dehydrogenase. Inhibition of glucose uptake by KL-11743 may synergize with therapies that induce oxidative stress (synthetic lethality).
orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Simultaneous determination of cyromazine and dicyclanil in animal edible tissues using UPLC-MS/MS
    Hou X, et al.
    Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 30(4), 660-665 (2013)
    P J James et al.
    Australian veterinary journal, 95(8), 265-272 (2017-07-28)
    To determine the prophylactic and therapeutic efficacy of Australian-registered insecticide formulations against Old World screwworm (OWS) myiases for potential use in screwworm containment and eradication programs. The longevity of protection provided by six insecticidal formulations (subcutaneous ivermectin, doramectin and abamectin
    Michael K Rust et al.
    Journal of medical entomology, 54(2), 418-421 (2016-12-25)
    Insect growth regulators (IGRs) such as lufenuron, methoprene, and pyriproxyfen have been important tools in the integrated pest management of cat fleas, Ctenocephalides felis (Bouché), for the past two decades. Other IGRs have been registered for the control of termite
    Matthew J Traylor et al.
    Insect biochemistry and molecular biology, 90, 14-22 (2017-09-18)
    The Australian sheep blowfly, Lucilia cuprina, is a primary cause of sheep flystrike and a major agricultural pest. Cytochrome P450 enzymes have been implicated in the resistance of L. cuprina to several classes of insecticides. In particular, CYP6G3 is a
    Neil H Bagnall et al.
    International journal for parasitology. Drugs and drug resistance, 7(1), 51-60 (2017-01-23)
    Histone deacetylase inhibitors (HDACi) are being investigated for the control of various human parasites. Here we investigate their potential as insecticides for the control of a major ecto-parasite of sheep, the Australian sheep blowfly, Lucilia cuprina. We assessed the ability
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