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SML3500

Sigma-Aldrich

Colesevelam hydrochloride

Synonym(s):

1-Hexanaminium, N,N,N-trimethyl-6-(2-propenylamino)-, chloride, polymer with (chloromethyl)oxirane, 2-propen-1-amine and N-2-propenyl-1-decanamine, hydrochloride, 2-Propen-1-amine, polymer with (chloromethyl)oxirane, N-2-propenyl-1-decanamine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride, hydrochloride, CholestaGel, Colesevelam HCl, GT 31-104

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About This Item

Linear Formula:
(C13H27N.C12H27N2.C3H7N.C3H5ClO.Cl)x.xHCl
CAS Number:
182815-44-7
UNSPSC Code:
12352200
NACRES:
NA.21
Pricing and availability is not currently available.

form

powder

Quality Level

100

mol wt

581.79 g/mol

storage condition

desiccated

color

white to beige

storage temp.

-10 to -25°C

SMILES string

C=CCNCCCCCCCCCC.C=CCNCCCCCC[N+](C)(C)C.NCC=C.ClCC1OC1.[xHCl].[Cl-]

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This Item
B019M003PHR1402
Colesevelam hydrochloride

SML3500

Colesevelam hydrochloride

Phenoxybenzamine hydrochloride ≥97%, powder

B019

Phenoxybenzamine hydrochloride

R-(−)-Deprenyl hydrochloride powder, ≥98% (HPLC)

M003

R-(−)-Deprenyl hydrochloride

Phenoxybenzamine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

PHR1402

Phenoxybenzamine Hydrochloride

form

powder

form

powder

form

powder

form

-

assay

≥98% (HPLC)

assay

≥97%

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

300

mol wt

581.79 g/mol

mol wt

-

mol wt

-

mol wt

-

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-30°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

Biochem/physiol Actions

Colesevelam hydrochloride, a polyamine polymer, is an oral, non-absorbed bile acid sequestrant. Colesevelam hydrochloride absorbs bile acids in the intestine, which increases demand for cholesterol synthesis and affectively lowers low-density lipoprotein cholesterol (LDL-C) blood levels.
Oral, non-absorbed bile acid sequestrant

Caution

Hygroscopic

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Sanjay Kalra et al.
    JPMA. The Journal of the Pakistan Medical Association, 70(5), 934-936 (2020-05-14)
    Colesevelam is a bile acid sequestrant, approved for the management of both dyslipidaemia and type 2 diabetes. This review discusses the potential for the use of colesevelam in the management of type 2 diabetes. Expert opinion suggests possible indications where
    Phillipp Hartmann et al.
    Hepatology international, 16(2), 359-370 (2022-01-26)
    Obesity, non-alcoholic fatty liver disease (NAFLD) and its more advanced form non-alcoholic steatohepatitis (NASH) are important causes of morbidity and mortality worldwide. Bile acid dysregulation is a pivotal part in their pathogenesis. The aim of this study was to evaluate

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