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SML3508

Sigma-Aldrich

Intepirdine

≥98% (HPLC)

Synonym(s):

3-(Phenylsulfonyl)-8-(1-piperazinyl)quinoline, 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline, GSK 742457, RVT 101, SB-742457

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About This Item

Empirical Formula (Hill Notation):
C19H19N3O2S
CAS Number:
Molecular Weight:
353.44
MDL number:
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.21

Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(C1=CC=CC=C1)(C2=CC3=C(N=C2)C(N4CCNCC4)=CC=C3)=O

InChI key

JJZFWROHYSMCMU-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
CLS71015CLS7101100CLS71011
feature

class A, graduation

feature

class A, graduation

feature

class A, graduation

feature

class A, graduation

manufacturer/tradename

Corning 7101-50

manufacturer/tradename

Corning 7101-5

manufacturer/tradename

Corning 7101-100

manufacturer/tradename

Corning 7101-1

material

glass

material

glass

material

glass

material

glass

capacity

50.0 mL

capacity

5.0 mL

capacity

100.0 mL

capacity

1.0 mL

packaging

pack of 2 ea

packaging

pack of 2 ea, case of 6 ea

packaging

pack of 2 ea, case of 6 ea

packaging

pack of 2 ea, case of 6 ea

volume measuring range

50.0 mL, accuracy: 0.05 mL

volume measuring range

5.0 mL, accuracy: 0.01 mL

volume measuring range

100.0 mL, accuracy: 0.08 mL

volume measuring range

1.0 mL, accuracy: 0.006 mL

Biochem/physiol Actions

Brain blood barrier penetrant, orally available, potent and selective serotonin receptor 6 (5-HT6) receptor antagonist
Intepirdine (SB-742457) is a brain blood barrier penetrant, orally available, potent and selective serotonin receptor 6 (5-HT6) receptor antagonist that potentiate cognitive and the behavioral abnormalities of AD in laboratory set up. Intepirdine has failed to demonstrate statistically significant impact on cognition or dementia in phase III trials. Intepirdine promotes satiety.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
Neurotherapeutics, 5(3), 458-469 (2008)
5-HT6 receptor agonist and antagonist improve memory impairments and hippocampal BDNF signaling alterations induced by MK-801
Brain Research, 1722, 146375-146375 (2019)

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