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Key Documents

SML3627

Sigma-Aldrich

JWH-133

≥98% (HPLC)

Synonym(s):

(6AR,10aR)-6,6,9-Trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene, (6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran, 3-(1’,1’-dimethylbutyl)-1-deoxy-Δ8-THC

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About This Item

Empirical Formula (Hill Notation):
C22H32O
CAS Number:
Molecular Weight:
312.49
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

[H][C@@]1(CC(C)=CC2)[C@@]2(C(C)(OC3=C1C=CC(C(C)(CCC)C)=C3)C)[H]

InChI

1S/C22H32O/c1-7-12-21(3,4)16-9-10-17-18-13-15(2)8-11-19(18)22(5,6)23-20(17)14-16/h8-10,14,18-19H,7,11-13H2,1-6H3/t18-,19+/m0/s1

InChI key

YSBFLLZNALVODA-RBUKOAKNSA-N

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form

foil

form

foil

form

foil

form

foil

assay

99.95%

assay

≥99.95%

assay

99.95%

assay

99.95%

manufacturer/tradename

Goodfellow 193-488-92

manufacturer/tradename

Goodfellow 060-230-67

manufacturer/tradename

Goodfellow 594-537-81

manufacturer/tradename

Goodfellow 059-906-21

mp

3410 °C (lit.)

mp

3410 °C (lit.)

mp

3410 °C (lit.)

mp

3410 °C (lit.)

resistivity

4.9 μΩ-cm, 20°C

resistivity

4.9 μΩ-cm, 20°C

resistivity

4.9 μΩ-cm, 20°C

resistivity

4.9 μΩ-cm, 20°C

bp

5660 °C (lit.)

bp

5660 °C (lit.)

bp

5660 °C (lit.)

bp

5660 °C (lit.)

Biochem/physiol Actions

JWH-133 is a potent and selective CB2 cannabinoid receptor agonist that suppresses inflammation in experimental colitis and pancreatitis in mice. JWH-133 appears to prevent neuroinflammation, Aβ accumulation, and impairment of cognitive function in transgenic AD models.
Selective CB2 cannabinoid receptor agonist

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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    Murat Çakır et al.
    Life sciences, 217, 25-33 (2018-12-01)
    Cannabinoid system has various physiological roles such as neurogenesis, synaptic plasticity and emotional state regulation in the body. The presence of cannabinoid type 2 receptor (CB2), a member of the cannabinoid system, was detected in different regions of the brain.

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