Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

SML3710

Sigma-Aldrich

Linaclotide

≥95% (HPLC)

Synonym(s):

CCEFCCNPACTGCF-OH cyclo(1-6),(2-10),(5-13)-tris(disulfide), Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH cyclo(1-6),(2-10),(5-13)-tris(disulfide), L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine-OH cyclo(1-6),(2-10),(5-13)-tris(disulfide)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C59H79N15O21S6
CAS Number:
851199-59-2
Molecular Weight:
1526.74
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

SMILES string

S1SC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H]3N(CCC3)C(=O)[C@@H](NC(=O)[C@H]4NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC4)N)C1)CCC(=O)O)Cc6ccc(cc6)O)CSSC[C@H](NC(=O)CNC(=O)C(NC2=O)[C@H](O)C)C(=O)N[C@@H](Cc5ccc(cc5)O)C(=O)O)CC(=O)N)C

InChI

1S/C59H79N15O21S6/c1-26-47(82)69-41-25-101-99-22-38-52(87)65-33(13-14-45(80)81)49(84)66-34(16-28-5-9-30(76)10-6-28)50(85)71-40(54(89)72-39(23-97-96-20-32(60)48(83)70-38)53(88)67-35(18-43(61)78)58(93)74-15-3-4-42(74)56(91)63-26)24-100-98-21-37(64-44(79)19-

InChI key

KXGCNMMJRFDFNR-IURAOCFRSA-N

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
D6319PLA0262WH0083594M1
Anti-Dcp2 serum, from rabbit

ABE2901

Anti-Dcp2

Anti-DCP2 (C-terminal) antibody produced in rabbit ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

D6319

Anti-DCP2 (C-terminal) antibody produced in rabbit

Rabbit anti-Dcp2 Antibody, Affinity Purified Powered by Bethyl Laboratories, Inc.

PLA0262

Rabbit anti-Dcp2 Antibody, Affinity Purified

Monoclonal Anti-NUDT12 antibody produced in mouse clone 3F7, purified immunoglobulin, buffered aqueous solution

WH0083594M1

Monoclonal Anti-NUDT12 antibody produced in mouse

antibody form

serum

antibody form

affinity isolated antibody

antibody form

affinity purified immunoglobulin

antibody form

purified immunoglobulin

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

species reactivity

mouse, human

species reactivity

rat, mouse, human

species reactivity

human

species reactivity

human

Gene Information

human ... DCP2(167227)

Gene Information

human ... DCP2(167227)
mouse ... Dcp2(20640)
rat ... Dcp2(291604)

Gene Information

rabbit ... Dcp2(167227)

Gene Information

human ... NUDT12(83594)

clone

polyclonal

clone

polyclonal

clone

-

clone

3F7, monoclonal

UniProt accession no.

Q8IU60

UniProt accession no.

Q8IU60

UniProt accession no.

Q8IU60

UniProt accession no.

Q9BQG2

Biochem/physiol Actions

Linaclotide is an orally active guanylate cyclase-C (GC-C) agonist that competes against bacterial STa enterotoxin binding to intestinal mucosal membranes from wild-type, but not GC-C null, mice (Ki = 16.4 nM). Linaclotide stimulates fluid secretion, upregulates cGMP accumulation in the intestinal lumen (5 μg/100 μL via injection into surgically ligated intestinal loops), and significantly increases the rate of gastrointestinal transit when administered orally in mice in vivo (100 μg/kg p.o.).
Orally active guanylate cyclase-C (GC-C) agonist that elicits in vivo pharmacological effects locally in the gastrointestinal tract.

Caution

Hygroscopic

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number

    It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

    If you need assistance, please contact Customer Support

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Verena Janes et al.
    Cells, 9(3) (2020-03-07)
    Genetic defects of human galactose-1-phosphate uridyltransferase (hGALT) and the partial loss of enzyme function result in an altered galactose metabolism with serious long-term developmental impairment of organs in classic galactosemia patients. In search for cellular pathomechanisms induced by the stressor

    Articles

    Glycosyltransferases

    Glycosyltransferases were initially considered to be specific for a single glycosyl donor and acceptor, which led to the one enzyme-one linkage concept. Subsequent observations have refuted the theory of absolute enzymatic specificity by describing the transfer of analogs of some nucleoside mono- or diphosphate sugar donors.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service