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SML3712

Sigma-Aldrich

NG-497

≥98% (HPLC)

Synonym(s):

6-(4-Ethoxyphenyl)-4-methoxy-2-pyridinecarboxylic acid, 1-methylethyl ester, Isopropyl 6-(4-ethoxyphenyl)-4-methoxypicolinate, NG 497, NG497

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About This Item

Empirical Formula (Hill Notation):
C18H21NO4
CAS Number:
2598242-66-9
Molecular Weight:
315.36
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.25

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C

InChI

1S/C18H21NO4/c1-5-22-14-8-6-13(7-9-14)16-10-15(21-4)11-17(19-16)18(20)23-12(2)3/h6-12H,5H2,1-4H3

InChI key

VYEIBLWRGBQRPI-UHFFFAOYSA-N

Biochem/physiol Actions

NG-497 is a non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor (IC50 = 1 μM, Ki = 0.5 μM) with little activity toward related human lipid hydrolases or ATGL orthologues from other species (<20% inhibition of mouse, rat, goat, pig, dog, marmoset ATGL at 50 μM). NG-497 abolishes hormone-induced lipolysis in human adipocytes (IC50 = 1.5 and 0.5 μM against 1 μM isoproterenol-induced total or hormonesensitive lipase (HSL)-independent FA release in Simpson-Golabi-Behmel syndrome adipocytes), but not in HepG2 that lacks ATGL hydrolase activity.
Non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Gernot F Grabner et al.
Journal of the American Chemical Society, 144(14), 6237-6250 (2022-04-02)
Chronically elevated circulating fatty acid levels promote lipid accumulation in nonadipose tissues and cause lipotoxicity. Adipose triglyceride lipase (ATGL) critically determines the release of fatty acids from white adipose tissue, and accumulating evidence suggests that inactivation of ATGL has beneficial

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