SML3964

Methylprednisolone acetate

≥98% (HPLC)

• Synonym(s): (6α,11β)-21-(Acetyloxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione acetate, 11β,17α,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate, 21-Acetoxy-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione acetate, 6-Methylprednisolone acetate, Depo-Medro acetatel
• Empirical Formula (Hill Notation): C₂₄H₃₂O₆
• CAS Number: 53-36-1
• Molecular Weight: 416.51
• MDL number: MFCD00200356
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D 85 to 105°, c = 0.5 in chloroform-d
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

Long-acting anti-inflammatory corticosteroid that suppresses lymphocytes-mediated immunologic responses.



Methylprednisolone acetate (Depo-Medrol) is a long-acting anti-inflammatory corticosteroid that suppresses lymphocytes-mediated immunologic responses. 6-Methylprednisolone acetate binds to intracellular glucocorticoid receptors and inhibits promoter domains of pro-inflammatory genes and hinders secretion of inflammatory cytokines. It effectively treats multiple ailments such as rheumatic and autoimmune diseases, leukemia, multiple myeloma, and Hodgkin’s and non-Hodgkin’s lymphoma symptoms along with other drugs. MPA improves COVID-19 pneumonia prognosis.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H361
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable