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SRP0455

BRD3 (29-145) His tag human

Name: BRD3 (29-145) His tag human
Brand: SIGMA

recombinant, expressed in E. coli, ≥88% (SDS-PAGE)

Synonym(s):

ORFX, RING3L, bromodomain containing 3

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About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

Pricing and availability is not currently available.

biological source

human

recombinant

expressed in E. coli

assay

≥88% (SDS-PAGE)

form

aqueous solution

mol wt

14.9 kDa

packaging

pkg of 100 μg

NCBI accession no.

NM_007371

UniProt accession no.

Q15059

shipped in

dry ice

storage temp.

−70°C

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This Item	HPA054820	SAB4300511	SAB4300233
HPA067595 Anti-MARCKS antibody produced in rabbit	HPA054820 Anti-MARCKS antibody produced in rabbit	SAB4300511 Anti-MARCKS (Ab-162) antibody produced in rabbit	SAB4300233 Anti-phospho-MARCKS (pSer¹⁵⁸) antibody produced in rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
product line Prestige Antibodies^® Powered by Atlas Antibodies	product line Prestige Antibodies^® Powered by Atlas Antibodies	product line -	product line -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
species reactivity human	species reactivity human	species reactivity mouse, human, rat	species reactivity human, rat, mouse

General description

Human Bromodomain containing 3, also known as BRD3 or RING3L (GenBank Accession No. NM_007371) amino-acids 29-145 with N-terminal HIS-tag, MW = 14.9 kDa, expressed in an E. coli expression system.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Specification Sheet

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Certificates of Analysis (COA)

Lot/Batch Number

3103020207

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Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3.

Roland Gamsjaeger et al.

Molecular and cellular biology, 31(13), 2632-2640 (2011-05-11)

Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability of bromodomains to recognize acetylated histones, it is increasingly becoming clear that

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.

Janine M Lamonica et al.

Proceedings of the National Academy of Sciences of the United States of America, 108(22), E159-E168 (2011-05-04)

Acetylation of histones triggers association with bromodomain-containing proteins that regulate diverse chromatin-related processes. Although acetylation of transcription factors has been appreciated for some time, the mechanistic consequences are less well understood. The hematopoietic transcription factor GATA1 is acetylated at conserved

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