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SRP0633

PD-L1 (D26A), FC Fusion, Biotin Labeled

Name: PD-L1 (D26A), FC Fusion, Biotin Labeled
Brand: SIGMA

recombinant, expressed in HEK 293 cells

Synonym(s):

B7 homolog 1, B7-H1, CD274, PD-L1, PDCD1L1, Programmed Cell Death 1 Ligand 1

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.26

Pricing and availability is not currently available.

recombinant

expressed in HEK 293 cells

form

frozen liquid

mol wt

54 kDa

UniProt accession no.

Q9NZQ7

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CD274(29126)

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1 of 4

This Item	SRP0643	SRP0641	SRP0635
SRP0633 PD-L1 (D26A), FC Fusion, Biotin Labeled	SRP0643 PD-L1 (K124A), FC Fusion, Biotin Labeled	SRP0641 PD-L1 (D122A), FC Fusion, Biotin Labeled	SRP0635 PD-L1 (Y56A), FC Fusion, Biotin Labeled
recombinant expressed in HEK 293 cells	recombinant expressed in HEK 293 cells	recombinant expressed in HEK 293 cells	recombinant expressed in HEK 293 cells
mol wt 54 kDa	mol wt 54 kDa	mol wt 54 kDa	mol wt 54 kDa
form frozen liquid	form frozen liquid	form frozen liquid	form frozen liquid
Gene Information human ... CD274(29126)	Gene Information human ... CD274(29126)	Gene Information human ... CD274(29126)	Gene Information human ... CD274(29126)
storage temp. −70°C	storage temp. −70°C	storage temp. −70°C	storage temp. −70°C
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice

General description

Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein, also known as CD274 and B7 homolog 1 (B7-H1) with a D26A mutation,GenBank Accession No. NM_014143,amino acids 19-239, fused at the Cterminus with the Fc portion of human IgG1,with C-terminal Avitag^™ expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avitag^™ technology. MW = 54 kDa.

Physical form

Aqueous solution

Legal Information

AviTag is a trademark of Avidity, LLC

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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A role for p11 in the antidepressant action of brain-derived neurotrophic factor.

Jennifer L Warner-Schmidt et al.

Biological psychiatry, 68(6), 528-535 (2010-07-02)

The protein p11 (also called S100A10) is downregulated in human and rodent depressive-like states. Considerable experimental evidence also implicates p11 in the mechanism of action of antidepressant drugs and electroconvulsive seizures, in part due to its interaction with specific serotonin

p11 and its role in depression and therapeutic responses to antidepressants.

Per Svenningsson et al.

Nature reviews. Neuroscience, 14(10), 673-680 (2013-09-05)

Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on the molecular and cellular mechanisms underlying depression. Here, we review data implicating p11 in both the amplification of serotonergic signalling and the regulation of gene transcription.

p11 and its role in depression and therapeutic responses to antidepressants

Svenningsson P, et al.

Nature Reviews. Neuroscience, 14(10), 673-680 (2013)

Disruption of annexin II/p11 interaction suppresses leukemia cell binding, homing and engraftment, and sensitizes the leukemia cells to chemotherapy

Gopalakrishnapillai A, et al.

Testing, 10(10), e0140564-e0140564 (2015)

Probable involvement of p11 with interferon alpha induced depression.

Jiqiang Guo et al.

Scientific reports, 6, 17029-17029 (2016-01-30)

Depression is one of the major side effects of interferon alpha (IFN-α) treatment, but the molecular mechanism underlying IFN-α-induced depression remains unclear. Several studies have shown that the serotonin receptors 5-HTR1b and 5-HTR4 play key roles in the anti-depression effects

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