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Key Documents

SRP2049

RAR, γ human

Name: RAR, γ human
Brand: SIGMA

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

Synonym(s):

NR1B3, RARC

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.26

Pricing and availability is not currently available.

biological source

human

recombinant

expressed in insect cells

assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~52.1 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

250 μg/mL

color

clear colorless

NCBI accession no.

NM_000966

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This Item	16-228	MABT524	CBL458
05-180-I Anti-Cortactin (p80/85) Antibody, clone 4F11	16-228 Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor^™ 488	MABT524 Anti-Cortactin (p80/85) Antibody, clone 5G3.2	CBL458 Anti-CD49f Antibody, clone 4F10
clone 4F11, monoclonal	clone 4F11, monoclonal	clone 5G3.2, monoclonal	clone 4F10, monoclonal
form liquid	form -	form -	form -
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
isotype IgG1κ	isotype IgG1	isotype IgG2bκ	isotype IgG2b
target post-translational modification unmodified	target post-translational modification -	target post-translational modification unmodified	target post-translational modification unmodified

Biochem/physiol Actions

Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consist of three isotypes (α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The RAR-gamma in the adult is found almost exclusively in the skin. Retinoids affect epidermal cell growth and differentiation as well as sebaceous gland activity and exhibit immunomodulatory and anti-inflammatory properties. Current retinoid research targets the development of receptor-selective retinoids for tailoring and/or improving their therapeutic profile.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

063254032

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The nuclear receptor ligand-binding domain: structure and function.

D Moras et al.

Current opinion in cell biology, 10(3), 384-391 (1998-06-26)

In the past few years our understanding of nuclear receptor action has dramatically improved as a result of the elucidation of the crystal structures of the empty (apo) ligand-binding domains of the nuclear receptor and of complexes formed by the

Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers.

C K Glass

Endocrine reviews, 15(3), 391-407 (1994-06-01)

The nuclear receptor superfamily: the second decade.

D J Mangelsdorf et al.

Cell, 83(6), 835-839 (1995-12-15)

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