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SRP2141

Sigma-Aldrich

RARα, ligand binding domain (154-462), GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(s):

NR1B1, RAR

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.26

Pricing and availability is not currently available.

biological source

human

recombinant

expressed in E. coli

assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~60.5 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

500 μg/mL

color

clear colorless

NCBI accession no.

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This Item
SRP2059SRP2048SRP2143
recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in insect cells

recombinant

expressed in E. coli

assay

≥80% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

human

concentration

500 μg/mL

concentration

500 μg/mL

concentration

1000 μg/mL

concentration

250 μg/mL

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

storage condition

avoid repeated freeze/thaw cycles

storage condition

avoid repeated freeze/thaw cycles

storage condition

avoid repeated freeze/thaw cycles

storage condition

avoid repeated freeze/thaw cycles

Biochem/physiol Actions

Several members of nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor α (RARα) in acute promyelocytic leukemia. Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consists of three isotypes (α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The retinoic acid receptor alpha gene is the target of chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). RAR α is a negative regulator of promyelocyte differentiation when not complexed with RA, and stimulates this differentiation when bound to RA.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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