SRP6058
Kallikrein-3 human
recombinant, expressed in human cells, ≥95% (SDS-PAGE)
Synonym(s):
APS, Hk3, KLK2A1, Kallikrein-3, P-30 antigen, PSA
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This Item | P3338 | SAB1405474 | WH0000354M2 |
|---|---|---|---|
| recombinant expressed in human cells | recombinant - | recombinant - | recombinant - |
| assay ≥95% (SDS-PAGE) | assay - | assay - | assay - |
| biological source human | biological source - | biological source mouse | biological source mouse |
| mol wt 35 kDa | mol wt - | mol wt antigen ~28.7 kDa | mol wt - |
| form lyophilized | form - | form buffered aqueous solution | form buffered aqueous solution |
| storage temp. −70°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
General description
Prostate-specific antigen, also known as Gamma-seminoprotein, Kallikrein-3, kallikrein-related peptidase 3, Semenogelase, KLK3 and PSA, is a secreted protein which belongs to thepeptidase S1 family and Kallikrein subfamily. KLK3/Kallikrein 3 contains one peptidase S1 domain. KLK3/Kallikrein 3 is a glycoprotein produced almost exclusively by the prostate gland. KLK3/Kallikrein 3 is produced for the ejaculate where it liquifies the semen in the seminal coagulum and allows sperm to swim freely.It is also believed to be instrumental in dissolving the cervical mucous, allowing the entry of sperm. Human KLK3/Kallikrein 3 and human KLK2 are closely related products of the human kallikrein genes KLK3 and KLK2, respectively. Both KLK3/Kallikrein 3 and human kallikrein 2 are produced and secreted in the prostate and have important applications in the diagnosis of prostate cancer. Understanding the mechanism by which genetic variation in KLK3/Kallikrein 3 affects prostate cancer risk has important implications for study of the biological role of KLK3/Kallikrein 3 in prostate tumorigenesis.
Physical form
Lyophilized from sterile PBS, pH 7.4. (Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.)
Preparation Note
Centrifuge the vial prior to opening.
Reconstitution
Detailed reconstitution instructions are sent along with the product.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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