SRP6340

IL18BP human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(s): IL18BPa, Interleukin-18-binding protein
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥90% (SDS-PAGE)
• form: liquid
• mol wt: 20 kDa (187 aa, 31-194 aa + His Tag)
• packaging: pkg of 100 μg
• concentration: 1 mg/mL
• UniProt accession no.: O95998
• shipped in: dry ice
• storage temp.: −70°C

Description

General description

IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn′s disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E.coli.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable