T0826

TBB

≥98% (HPLC), solid

• Synonym(s): 4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634, TBBt
• Empirical Formula (Hill Notation): C₆HN₃Br₄
• CAS Number: 17374-26-4
• Molecular Weight: 434.71
• MDL number: MFCD06411399
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724628
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: 28 mg/mL
• storage temp.: 2-8°C
• SMILES string: Brc1c(Br)c(Br)c2[nH]nnc2c1Br
• InChI: 1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
• InChI key: OMZYUVOATZSGJY-UHFFFAOYSA-N

Description

Application

TBB was used to study casein kinase 2-dependent phosphorylation of DNA damage mediator protein MDC1.

Biochem/physiol Actions

TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.

TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC₅₀ = 900 nM and 1.6 mM, using rat liver and recombinant human CK2, respectively).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: Eyeshields, Gloves, type N95 (US)