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T3694

Sigma-Aldrich

Tetanus toxin C fragment from Clostridium tetani

Synonym(s):

TTC

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About This Item

MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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mol wt

apparent mol wt 47 kDa

Quality Level

color

white

solubility

H2O: soluble

storage temp.

2-8°C

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This Item
SAB3500585ABT335SAB1402860
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

species reactivity

rat, human

species reactivity

mouse, rat, human

species reactivity

human, mouse

species reactivity

human

General description

Tetanus toxin C fragment (TTC) is a non-toxic peptide, which is transported from peripheral axons into spinal motoneurons. It provides protection for motoneurons (MN) in the spinal cord in vivo. TTC regulates membrane binding, internalization and retrograde transport within MN. It initiates neurotrophin-regulated signaling pathways in a Trk receptor-dependent manner. TTC has neuroprotective property in primary cerebellar granule cell culture.[1]

Application

The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin.
The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin. It is used to map neuronal connections and to target proteins to neurons.

Biochem/physiol Actions

Tetanus toxin is a neurotoxin that comprises of a heavy and a light chain linked by disulfide bridges. This neurotoxin enters the cytoplasm and releases the light chain component that subsequently inhibits the release of neurotransmitters2. Studies have reported that the fragment C of tetanus toxin retains most of the determinants that interact with thyroid membranes, gangliosides and neural membranes3.

Reconstitution

Each vial, when reconstituted with 50 μl of sterile distilled water, contains 10 μg of tetanus toxin C-fragment in 0.01 M sodium phosphate, pH 7.5. To aid recovery, 0.1% albumin may be added.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1

target_organs

Central nervous system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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