T4264

Tetrahydrozoline hydrochloride

≥98% (HPLC)

• Synonym(s): 4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole monohydrochloride, Tetryzoline hydrochloride
• Empirical Formula (Hill Notation): C₁₃H₁₆N₂ · HCl
• CAS Number: 522-48-5
• Molecular Weight: 236.74
• EC Number: 208-329-3
• MDL number: MFCD00058029
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278736
• NACRES: NA.77

Properties

• Quality Level: 200
• assay: ≥98% (HPLC)
• solubility: H₂O: freely soluble; alcohol: freely soluble; chloroform: very slightly soluble; diethyl ether: insoluble
• originator: Novartis
• SMILES string: Cl.C1CC(C2=NCCN2)c3ccccc3C1
• InChI: 1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H
• InChI key: BJORNXNYWNIWEY-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Biochem/physiol Actions

Tetrahydrozoline is an α-adrenergic agonist and an imidazoline derivative. It plays a crucial role in the constriction of conjunctival blood vessels. Tetrahydrozoline is a common component of nasal and eye drop formulations.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves