T4930
Anti-Thrombopoietin antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-TPO
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About This Item
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
indirect ELISA: suitable
neutralization: suitable
western blot: suitable
UniProt accession no.
General description
This antibody will neutralize the biological activity of recombinant mouse TPO. By ELISA, the antibody shows <15% cross-reactivity with recombinant human TPO.
Immunogen
recombinant mouse TPO.
Biochem/physiol Actions
Thrombopoietin is a humoral growth factor that is synthesized in the liver and regulates the proliferation and maturation of megakaryocytes, and production of platelets. It modulates the response of platelets to various stimuli by regulating the homeostatic potential.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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G Carpenter et al.
Analytical biochemistry, 153(2), 279-282 (1986-03-01)
A bioassay for epidermal growth factor (EFG) which is rapid, specific, and extremely sensitive is described. As the bioassay detects as little as 25 pg of EGF, this assay is more sensitive than commonly used radioreceptor assays and nearly as
S Cohen et al.
Proceedings of the National Academy of Sciences of the United States of America, 72(4), 1317-1321 (1975-04-01)
A polypeptide hormone has been isolated from human urine, human epidermal growth factor. It was assayed by its ability to compete with 125I-labeled mouse-derived epidermal growth factor in binding to human foreskin fibroblasts. The biological effects of the human polypeptide
G L Brown et al.
The New England journal of medicine, 321(2), 76-79 (1989-07-13)
Experimental studies in animals have demonstrated that the topical application of epidermal growth factor accelerates the rate of epidermal regeneration of partial-thickness wounds and second-degree burns. We conducted a prospective, randomized, double-blind clinical trial using skin-graft-donor sites to determine whether
Bernhard Wörmann
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 40(5), 319-325 (2013-11-26)
Thrombocytopenia is a common hematologic disorder. Stimulation of thrombopoiesis may reduce the risk for thrombocytopenia-induced bleeding, prevent severe thrombocytopenia, and reduce the need for platelet transfusion. The key cytokine is thrombopoietin (TPO). It regulates proliferation and maturation of megakaryocytes as
The epidermal growth factor receptor as a multifunctional allosteric protein.
J Schlessinger
Biochemistry, 27(9), 3119-3123 (1988-05-03)
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