Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

T7040

Sigma-Aldrich

Tyrphostin 1

≥98%

Synonym(s):

(4-Methoxybenzylidene)malononitrile

Sign Into View Organizational & Contract Pricing

About This Item

Linear Formula:
CH3OC6H4CH=C(CN)2
CAS Number:
2826-26-8
Molecular Weight:
184.19
MDL number:
MFCD00019787
UNSPSC Code:
12352200
PubChem Substance ID:
24278751
NACRES:
NA.77
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

200

assay

≥98%

form

solid

potency

>1250 μM IC50 (negative control)

mp

113-116 °C (lit.)

solubility

chloroform: soluble 50 mg/mL, clear, light yellow
DMSO: soluble

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)\C=C(/C#N)C#N

InChI

1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3

InChI key

UOHFCPXBKJPCAD-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
T4182A3355N1537
Tyrphostin 1 ≥98%

T7040

Tyrphostin 1

Tyrphostin AG 1478 ≥98%

T4182

Tyrphostin AG 1478

ATC0175 ≥98% (HPLC), solid

A3355

ATC0175

NU7026 ≥98% (HPLC), solid

N1537

NU7026

form

solid

form

solid

form

solid

form

solid

assay

≥98%

assay

≥98%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

chloroform: soluble 50 mg/mL, clear, light yellow, DMSO: soluble

solubility

0.1 M HCl: soluble <0.4 mg/mL, DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless, ethanol: soluble 10 mg/mL, methylene chloride: soluble 10 mg/mL, 0.1 M NaOH: insoluble, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble

solubility

DMSO: soluble 5 mg/mL, H2O: insoluble

solubility

DMSO: soluble 3 mg/mL at 60 °C, H2O: insoluble

potency

>1250 μM IC50 (negative control)

potency

-

potency

-

potency

-

Application

Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells[1].

Biochem/physiol Actions

EGFR tyrosine kinase inhibitor.
Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation[2],[3]. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells[4],[5].

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    082H0448
    057H0292
    053K3691
    049H1315
    035H0706

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Articles

    DNA Standards for Metagenomic Research into Microbiome Communities

    The use of standards is critical to the integrity of metagenomics research. Learn how DNA standards for bacteria, fungi, and viruses are applied to studying the microbiome. Choose standards for E. coli and other key species, as well as mixed community standards.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service