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WH0007486M9

Sigma-Aldrich

Monoclonal Anti-WRN antibody produced in mouse

clone 3C11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-RECQ3, Anti-RECQL2, Anti-RECQL3, Anti-Werner syndrome

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About This Item

MDL number:
MFCD02264220
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3C11, monoclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

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1 of 4

This Item
EMU047941EMU021181EMU000011
MISSION® esiRNA targeting mouse Mfap4

EMU059551

MISSION® esiRNA

MISSION® esiRNA targeting mouse Dnttip1

EMU047941

MISSION® esiRNA

MISSION® esiRNA targeting mouse Mfap5

EMU021181

MISSION® esiRNA

MISSION® esiRNA targeting mouse Lass2

EMU000011

MISSION® esiRNA

Gene Information

mouse ... MFAP4(76293), Mfap4(76293)

Gene Information

mouse ... DNTTIP1(76233), Dnttip1(76233)

Gene Information

mouse ... MFAP5(50530), Mfap5(50530)

Gene Information

mouse ... LASS2(76893), Lass2(76893)

esiRNA cDNA target sequence

CTCCACGCTTTACCCACAATTCCTGAGCACCAGCCATGCCCTGGCAAATCCCTGTCCCACATACAGCCACGCCCTGATGCATTCCACCTGAGGCTAGGCTGTCAGCAGCCCTCCAGGCCTTTCTGTGGCTGAGCCATCCTAGCCTGGATCTGGCTGAAATCCATTAAAAACTCCAAGTTGCTTCTACCCCTTCACGACAGCTGAAAGCCAGAAGCTACCTTCTAGCTGCCAGCTTTTGCACCCCACCTCAGCAGTTTCCTTACTGCAGAGCCTTCTGTTTGGGGCTACCCTCGACAGAGTCATGCAGCACCTGTGGCATTGCCAATCAGCTCTTGCACACTGCCACACCCCAGCACTCACATAGCTCTCCTCAGAATACTTCCTACCTTGGCCTCATCAC

esiRNA cDNA target sequence

CAGCTCGGCTGAATGAATCTACCACCTTTGTTTTGGGGTCTCGAGCCAACAAGGCCTTGGGGATGGGAGGCACCAGAGGGAGAATCTACATCAAGCACCCACACCTCTTTAAGTATGCAGCAGATCCTCAGGACAAGCACTGGCTGGCTGAGCAGCATCACATGCGGGCAACAGGCGGAAAGATGGCGTACCTTCTCATTGAAGAAGACATCCGGGACTTGGCTGCCAGCGATGACTACAGAGGATGCTTGGACCTGAAGTTGGAGGAGCTGAAATCCTTTGTTCTGCCATCCTGGATGGTTGAGAAGATGCGGAAATACATGGAGACACTGCGGACAGAAAATGAGCACCGCGCTGCGGAAGCGCCTCCCCAGACCTGAGCCGGGTGTCCTGGCTACTACACTTGGCGGCCTG

esiRNA cDNA target sequence

TTACGGCGCATGTACATCATCAATAATGAGATCTGTTCCCGACTCGTCTGTAAAGAACATGAAGCTATGAAAGATGAGCTTTGCCGGCAGATGGCAGGCCTGCCTCCAAGGCGACTTCGGCGCTCCAACTACTTCCGACTTCCTCCCTGTGAAAATATGAATTTGCAGAGACCCGATGGTCTGTGATCACCAAGGAAGAAAGAAGAAAATGTGGATGAAGGAATCGAAAATTCTTTCTCCTCCAACCCCTGCCATCTGTCCCGTAGACATGTATTTTTAAACTAAGCCCTTTGCAATGCCCCGGCTTCCTACCCTACTCTAATTTTCACTGGTGCTGGTAACGTTTGTCTCATTTTGCGGTACTGACAATACATTGTCTATATTGTGGCACGGGTTTGCTGATTTCTGGTGTTGTAGACAAGATGGATAAAGGATGGCCACTTG

esiRNA cDNA target sequence

CTTCAGCATTGCCTCTGATGTCAAGCGAAAGGATTTTAAGGAACAGATCATCCACCATGTGGCCACTATCATTCTCCTCTGCTTCTCCTGGTTTGCCAATTACGTCCGGGCAGGGACCCTCATCATGGCTCTGCATGACGCTTCTGACTACCTGCTGGAGTCTGCCAAGATGTTTAACTACGCGGGATGGAAGAACACCTGCAACAACCTCTTCATTGTGTTCGCCATCGTTTTCATCATCACTCGGCTGGTTATCATGCCTTTCTGGATCCTACACTGCACGATGATATACCCACTGGAGCTCTACCCTGCCTTCTTTGGCTATTATTTCTTCAATTTTATGATGGCAGTGCTACAGATGCTCCATATCTTCTGGGCCTACTTCATTCTGCGTATGGCC

Ensembl | mouse accession no.

ENSMUSG00000042436

Ensembl | mouse accession no.

ENSMUSG00000017299

Ensembl | mouse accession no.

ENSMUSG00000030116

Ensembl | mouse accession no.

ENSMUSG00000015714

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

NCBI accession no.

NM_029568

NCBI accession no.

NM_133763

NCBI accession no.

NM_015776

NCBI accession no.

NM_029789

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3′ to 5′ DNA helicase activity, and is also a 3′ to 5′ exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. (provided by RefSeq)

Immunogen

WRN (NP_000544, 1322 a.a. ~ 1432 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
NPPVNSDMSKISLIRMLAPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    10218-3C11
    08297-3C11
    07018-3C11

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    B H van Leeuwen et al.
    Blood, 73(5), 1142-1148 (1989-04-01)
    The human genes for the hematopoietic growth factors interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been mapped to 5q23-31. We present in situ hybridization evidence that the human IL-4 gene is located at 5q23.3-31.2, suggesting that the four
    K Kaushansky et al.
    Proceedings of the National Academy of Sciences of the United States of America, 83(10), 3101-3105 (1986-05-01)
    Through the use of long single-sequence oligonucleotide probes, the complete gene for human granulocyte-macrophage colony-stimulating factor (hGM-CSF) has been cloned from a human genomic library. The gene is 2.5 kilobases in length, contains three introns, and is present as a
    Sabine Hoffjan et al.
    American journal of human genetics, 76(4), 696-704 (2005-02-24)
    Asthma is a common disease that results from both genetic and environmental risk factors. Children attending day care in the 1st year of life have lower risks for developing asthma, although the mechanism for this "day care" effect is largely

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