SAB4504429

Anti-phospho-Histone H3.1 (pSer¹⁰) antibody produced in rabbit

affinity isolated antibody

• Từ đồng nghĩa: Anti-H3.1, Anti-H3/c, Anti-H3C1, Anti-H3C10, Anti-H3C11, Anti-H3C12, Anti-H3C2, Anti-H3C4, Anti-H3C6, Anti-H3C8, Anti-H3FC, Anti-HIST1H3C
• UNSPSC Code: 12352203
• NACRES: NA.41

Tính chất

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 15 kDa
• species reactivity: human, rat, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P68431; P84243; Q71DI3
• UniProt accession no.: P68431
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer10)
• Gene Information: human ... HIST1H3A(8350), HIST1H3B(8358), HIST1H3C(8352), HIST1H3D(8351), HIST1H3E(8353), HIST1H3G(8355), HIST1H3H(8357), HIST1H3I(8354), HIST1H3J(8356), HIST1H4A(8359)

Mô tả

General description

Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). H3.1 is also called as HIST1H3E. It is mainly expressed in the S phase. HIST1H3E is located on human chromosome 6p22.

Immunogen

The antiserum was produced against synthesized peptide derived from human Histone H3.1 around the phosphorylation site of Ser10.

Immunogen Range: 1-50

Biochem/physiol Actions

Histone proteins are basic building blocks of chromatin. Mutations in histone H3 results in adult cerebellar high-grade gliomas. It controls protein-protein interactions to induce binding of trans-acting factors that drive chromatin condensation. H3.1 acts as a replication-dependent histone.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Thông tin về tính an toàn

• Lớp lưu trữ: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable