TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
Synonymes:
CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Espèce(s):
Human TNFSF11 (8600), Mouse Tnfsf11 (21943), Rat Tnfsf11 (117516), Zebrafish tnfsf11 (100331628), dog TNFSF11 (609418), chicken TNFSF11 (428067), naked mole-rat Tnfsf11 (101696350), domestic guinea pig Tnfsf11 (100713226), cow TNFSF11 (513836)
ID UniProtKB:
ID du gène:
- Human(8600) Summary: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
- Mouse(21943) tumor necrosis factor (ligand) superfamily, member 11
- Rat(117516) tumor necrosis factor (ligand) superfamily, member 11
- Zebrafish(100331628) tumor necrosis factor (ligand) superfamily, member 11
- dog(609418) tumor necrosis factor (ligand) superfamily, member 11
- chicken(428067) tumor necrosis factor (ligand) superfamily, member 11
- naked mole-rat(101696350) tumor necrosis factor (ligand) superfamily, member 11
- domestic guinea pig(100713226) tumor necrosis factor (ligand) superfamily, member 11
- cow(513836) tumor necrosis factor (ligand) superfamily, member 11
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Antibodies
Product Number
Description
Espèces réactives
Application
Anti-RANKL Antibody, clone 6A12.1, clone 6A12.1, from mouse,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-RANKL/TNFSF11 Antibody, clone 1H17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
bovine, human, monkey, porcine
Application
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TNFSF11 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-TNFSF11 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot
Proteins
Product Number
Description
Espèce(s)
RANK Ligand from mouse, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture,
Espèce(s)
mouse
sRANKL human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Espèce(s)
human
RANK Ligand/TRANCE human, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
Espèce(s)
human
Protéine RANK Ligand soluble (sRANKL), humaine recombinante, The recombinant human sRANKL protein is produced in E. Coli.,
Espèce(s)
human
sRank Ligand from rat, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Espèce(s)
rat
esiRNA
Product Number
Description
Espèce(s)