739960

Resomer^® RG 505, Poly(D,L-lactide-co-glycolide)

ester terminated, M_w 54,000-69,000

• Synonym(s): PLGA
• Linear Formula: [C₃H₄O₂]_x[C₂H₂O₂]_y
• CAS Number: 26780-50-7
• MDL number: MFCD00131930
• UNSPSC Code: 12162002
• NACRES: NA.23

Properties

• Quality Level: 100
• form: amorphous
• feed ratio: lactide:glycolide 50:50
• mol wt: M_w 54,000-69,000
• degradation timeframe: <3 months
• viscosity: 0.61-0.74 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)
• transition temp: T_g 48-52 °C
• storage temp.: 2-8°C
• SMILES string: O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O
• InChI: 1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2
• InChI key: LCSKNASZPVZHEG-UHFFFAOYSA-N

Description

General description

Poly(lactide-co-glycolide)(PLGA) is a biodegradable polymer used in the preparation of polymericmicrospheres. These polymers degrade in vivo by hydrolysis of their esterbackbone into non-toxic products, which are excreted by the kidneys oreliminated as CO₂ and water through biochemical pathways. PLGAmicrospheres have been widely used to encapsulate drug molecules and have beenused as long-acting, sustained-release pharmaceutical formulations.

Application

Poly(lactide-co-glycolide)(PLGA) can be used to fabricate sustained-release drug delivery systems, for example, it can be used to encapsulate the anti-inflammatory lipophilic drug atorvastatin.

Legal Information

Product of Evonik

RESOMER is a registered trademark of Evonik Rohm GmbH

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable