AB10000

Anti-CHIP/STUB1 Antibody

Chemicon^®, from goat

• Synonym(s): CHIP, STUB1
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: goat
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human, chimpanzee
• manufacturer/tradename: Chemicon^®
• technique(s): ELISA: suitable; western blot: suitable
• NCBI accession no.: NM_005861.2
• UniProt accession no.: Q9UNE7
• shipped in: dry ice
• target post-translational modification: unmodified
• Gene Information: human ... STUB1(10273)

Description

General description

U box domain E3 ubiquitin ligase. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association. Also, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins.

Immunogen

Peptide with sequence DAFISENGWVEDY, from the C-terminus of the protein sequence according to NP_005852.

Application

This Anti-CHIP/STUB1 Antibody is validated for use in ELISA, WB for the detection of CHIP/STUB1.

Physical form

Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Analysis Note

Control
Positive Control: Highly expressed in brain, heart, skelatal muscle, pancreas and placenta. Weak expression in kidney, liver and lung.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable