C4650

Cholestyramine resin

• Synonym(s): Colestyramine, Dowex 1X2 Cl^--Form
• CAS Number: 11041-12-6
• EC Number: 234-270-8
• MDL number: MFCD00130784
• UNSPSC Code: 23151817
• NACRES: NA.56

Properties

• form: powder
• Quality Level: 200
• technique(s): activity assay: suitable
• matrix: polystyrene/divinylbenzene
• pH: 4—6
• capacity: ~1.0 meq/g(dry)

Description

Application

Cholestyramine resin has been used:

• as a diet supplement to study the bile acid pool size and fecal bile acid output in mice
• to alter the bile acid (BA) levels and study its effect on liver fibrosis development in wild type (WT), fibroblast growth factor 15 (Fgf15)−/−, and Fgf15 transgenic (TG) mice
• in in vitro digestion process to study the capacity of the fractions for binding bile acid (BA)

Cholestyramine resin is used in protein chromatography, ion exchange chromatography and anion exchange media. Cholestyramine has been used to study the relief of postcholecystectomy diarrhea, the management of intractable cholestatic pruritus and obesity.

Biochem/physiol Actions

Cholestyramine is a cationic exchange resin polymer. This resin is a bile acid sequestrant that interchanges chloride anions for bile acids of the small intestine lumen, leading to excretion of bile acids in the feces and reduced levels of serum bile acid. Cholestyramine is used to treat primary hypercholesterolemia. The resin induces dose-dependent reduction of low-density lipid (LDL) cholesterol. It ameliorates the risk of coronary artery disease.

Other Notes

Quartenary ammonium functional groups attached to cross-linked polystyrene

Legal Information

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves