F3680

10058-F4

≥98% (HPLC), solid

• Synonym(s): 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
• Empirical Formula (Hill Notation): C₁₂H₁₁NOS₂
• CAS Number: 403811-55-2
• Molecular Weight: 249.35
• MDL number: MFCD00758517
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799701
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: yellow
• solubility: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCc1ccc(cc1)\C=C2\SC(=S)NC2=O
• InChI: 1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
• InChI key: SVXDHPADAXBMFB-JXMROGBWSA-N

Description

Application

10058-F4 has been used:

• as c-Myc inhibitor to treat stromal cells
• as c-Myc inhibitor to determine the effect of c-Myc inhibition on cardiac progenitor cells (CPC) growth
• as c-Myc inhibitor to culture T cells
• to treat C4-2 cells to examine the activity of MST1 promoter luciferase reporter construct

Biochem/physiol Actions

10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).

10058-F4 is a c-Myc inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317,H319
• Precautionary Statements: P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves