G3798

10074-G5

≥98% (HPLC)

• Synonym(s): Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine, N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-amine, N-[1,1′-Biphenyl-2-yl]-7-nitro-2,1,3-Benzoxadiazol-4-amine
• Empirical Formula (Hill Notation): C₁₈H₁₂N₄O₃
• CAS Number: 413611-93-5
• Molecular Weight: 332.31
• MDL number: MFCD00576774
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799918
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: red
• solubility: DMSO: >10 mg/mL
• storage temp.: room temp
• SMILES string: [O-][N+](=O)c1ccc(Nc2ccccc2-c3ccccc3)c4nonc14
• InChI: 1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H
• InChI key: KMJPYSQOCBYMCF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.

Safety Information

• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3