N3510

Niclosamide

• Synonym(s): 2′,5-Dichloro-4′-nitrosalicylanilide
• Empirical Formula (Hill Notation): C₁₃H₈Cl₂N₂O₄
• CAS Number: 50-65-7
• Molecular Weight: 327.12
• Beilstein: 2820605
• EC Number: 200-056-8
• MDL number: MFCD00057597
• UNSPSC Code: 51102829
• PubChem Substance ID: 24278585
• NACRES: NA.85

Properties

• form: powder
• Quality Level: 200
• antibiotic activity spectrum: parasites
• Mode of action: enzyme | inhibits
• SMILES string: Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O
• InChI: 1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
• InChI key: RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Description

Application

Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit transcription and DNA binding of the NF-?B pathway and it increases ROS levels to induce apoptosis in acute myelogenous leukemia (AML) cells.

Biochem/physiol Actions

Niclosamide uncouples oxidative phosphorylation in the tapeworm and inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κΒ– regulated genes in AML cells.

Other Notes

50g,250g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves