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SCP0158

Sigma-Aldrich

Granzyme B Substrate

≥95% (HPLC), lyophilized

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250 μG
MYR 2,889.00

MYR 2,889.00


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250 μG
MYR 2,889.00

About This Item

Empirical Formula (Hill Notation):
C32H41N5O11
Molecular Weight:
671.69
UNSPSC Code:
12352204
NACRES:
NA.32

MYR 2,889.00


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Product Name

Granzyme B Substrate,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

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1 of 4

This Item
SCP0101SCP0257SCP0185
assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

protect from light

storage condition

protect from light

storage condition

protect from light

storage condition

protect from light

composition

Peptide Content, ≥85%

composition

Peptide Content, ≥80%

composition

Peptide Content, ≥65%

composition

Peptide Content, ≥75%

Amino Acid Sequence

Ac-Ile-Glu-Pro-Asp-AMC

Application

Granzyme B Substrate (Ac-IEPD-AMC) is a fluorogenic substrate for the detection and assay of caspase 8 and granzyme B which is involved in the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Biochem/physiol Actions

Granzymes belongs to serine proteinase family enzymes and it localizes along with perforin in granules. It is predominant in cytotoxic T cells. Granzyme B induces caspases dependent and independent cell death. It possesses specific cleavage action at aspartate residue in the substrate.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Synaptic inputs onto small bistratified (blue-ON/yellow-OFF) ganglion cells in marmoset retina.
Percival KA, Jusuf PR, Martin PR, Grunert U
The Journal of Comparative Neurology null
Synaptic contact between melanopsin-containing retinal ganglion cells and rod bipolar cells.
?stergaard, J; Hannibal, J; Fahrenkrug, J
Investigative Ophthalmology & Visual Science null
F Yang et al.
Nature neuroscience, 4(11), 1071-1078 (2001-10-11)
Glial cell line-derived neurotrophic factor (GDNF) prevents lesion-induced death of midbrain dopaminergic neurons, but its function in normal brain remains uncertain. Here we show that GDNF acutely and reversibly potentiated the excitability of cultured midbrain neurons by inhibiting transient A-type
Cell-type-specific localization of protocadherin ?16 at AMPA and AMPAKainate receptor-containing synapses in the primate retina.
Puller C, Haverkamp S
The Journal of Comparative Neurology null
ZO-1 and the spatial organization of gap junctions and glutamate receptors in the outer plexiform layer of the mammalian retina.
Puller, C; de Sevilla Muller, LP; Janssen-Bienhold, U; Haverkamp, S
The Journal of Neuroscience null

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