SML0579

EVP4593

≥98% (HPLC)

• Synonym(s): 4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine, N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine, QNZ
• Empirical Formula (Hill Notation): C₂₂H₂₀N₄O
• CAS Number: 545380-34-5
• Molecular Weight: 356.42
• MDL number: MFCD06411436
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825563
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC1=CC(C(NCCC2=CC=C(OC3=CC=CC=C3)C=C2)=NC=N4)=C4C=C1
• InChI: 1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
• InChI key: IBAKVEUZKHOWNG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca²⁺) entry (SOC).

EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca²⁺) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.

Features and Benefits

This compound is featured on the Calcium Channels, Cytokine Receptors (Interleukin-1 Receptor/TIR Family) and Cytokine Receptors (Tumor Necrosis Receptor Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Air sensitive

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable