SML1224

Torin2

≥98% (HPLC)

• Synonym(s): 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
• Empirical Formula (Hill Notation): C₂₄H₁₅F₃N₄O
• CAS Number: 1223001-51-1
• Molecular Weight: 432.40
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N
• InChI: 1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
• InChI key: GUXXEUUYCAYESJ-UHFFFAOYSA-N

Description

Application

Torin2 has been used:

• to examine its effect on LC3B-II levels in BORCS5- KO cells
• to determine its potent activity (IC₅₀ less than 1 μM) against A2780-cis ovarian cancer cells
• in western blot analysis

Biochem/physiol Actions

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor.

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC₅₀ of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable